COX-1 vs. COX-2 as a determinant of basal tone in the internal anal sphincter
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COX-1 vs. COX-2 as a determinant of basal tone in the internal anal sphincter.
Prostanoids, produced endogenously via cyclooxygenases (COXs), have been implicated in the sustained contraction of different smooth muscles. The two major types of COXs are COX-1 and COX-2. The COX subtype involved in the basal state of the internal anal sphincter (IAS) smooth muscle tone is not known. To identify the COX subtype, we examined the effect of COX-1- and COX-2-selective inhibitors...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Gastrointestinal and Liver Physiology
سال: 2009
ISSN: 0193-1857,1522-1547
DOI: 10.1152/ajpgi.90485.2008